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-DESCRIPTION:
Our product, EGCG is a kind of component extracted from the Chinese green tea. It is the mainly active and water-soluble component from green tea, whose content is the highest in the tea catechins. It accounts for 9-13% of green tea in net weight. By virtue of its peculiar stereochemical structure, EGCG possesses much stronger anti-oxidant activities and plays an important role in preventing from cancer and cardiovascular diseases. In addition,it is potently used as the reversal agent of MDR (Multidrug Resistance), which may improve the sensitivity of the cancer cell to the chemotherapy drug and reduce the toxicity on the heart.
Product Information:
CAS Number: 989-51-5
synonym: (2R, 3R)-2-(3,4,5-Trihydroxy-phenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
3-(3,4, 5-trihydroxybenzoate),(-)-Epigallocatechin gallate, (-)-Epigallocatechin
gallate 3-O-gallate
Molecular Formula: C22H18O11
Molecular Weight: 458.4
Solubility: Clear colorless solution at 5Mg/Ml in water
Test Item:Appearance, Loss on drying, Total Ash, Assay, Heavy Metals, Arsenic,
Microbiological
Storage: Store in a cool and dry area, keep sealed and keep away from direct light .
Puriry: 15%,30%9,45%,50%, 60%,70%,90%,98%.
Biological effects:
(-)-Epigallocatechin gallate (EGCG), an most potent antioxidant polyphenols of green tea, is associated with antioxidant, antitumor and antimutagenic activities. The antioxidant activity is at last 100 more times more effective than vitamin C and 25 times more effective than vitamin E at protecting cells and DNA from damage which are believed to be linked to cancer, heart disease and other potentially fatal illnesses. The biological benefits of EGCG are generally attributed to their antioxidant activity to scavenge free radical oxygen.
EGCG is the major component of the polyphenolic fraction of green tea. It make up about 10-50% of the total green tea catechins includeing epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate(ECG), epicatechin(EC), gallocatechin gallate (GCG), catechin are major catechin of green tea catechin. The antioxidant activity increased in the following order: EC<ECG<EGC<EGCG.
Many studies indicate EGCG play a role as,protect aganist free-radical DNA damage;protect aganist the effects of ionizing radiation and ultraviolet radiation;inhibit lipid peroxidation, decrease serum cholesterol levels, LDL, VLDL and triglycerides;interfere with the binding of cancer-causing agents to cellular DNA, help to neutralize dietary carcinogens;work with enzymes and other antioxidants in the intestine, liver and lungs to prevent the activation of certain carcinogens before they damage DNA;as a free radicals scavenger, combat the effects of pollution, sunlight and smoking, help skin from wrinkling and aging;
Safety:
Green tea consumption of as much as 20 cups per day has not been assoiated with any significant side effects. Acute studies reported the oral LD50 of EGCG in mice was 2170mg/kg bw.
Application:
Medicine, Health food, Food, Beverage, Cosmetics and Beverage, etc.
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